Cleven 20mg/0.2ml Injection

✔️ Use of Cleven 20mg/0.2ml Injection

• Treatment and prevention of blood Clots

✔️ How does Cleven 20mg/0.2ml Injection work?

Cleven 20mg/0.2ml Injection is an anticoagulant medication that works by inhibiting the formation of new blood clots and preventing existing ones from growing larger. It does this by blocking a substance in the body involved in blood clotting, which promotes smooth blood flow throughout the body. This medication can reduce the damage caused by blood clots in various parts of the body, including the lungs, brain, heart, and other blood vessels. It is also used to prevent clots from forming after surgery, such as knee or hip joint replacement. While it does not dissolve blood clots, it can prevent them from enlarging, allowing the body to break them down over time. Additionally, it can reduce the likelihood of parts of a clot breaking off and traveling to other parts of the body.

✔️ Side Effects of Cleven 20mg/0.2ml Injection

Cleven 20mg/0.2ml Injection may cause some side effects. Common side effects may include bleeding, bruising, injection site reactions (such as pain or redness), pink patches on the skin (especially in the injection site), skin rash, itching, redness, low red blood cell count in the blood, and headache.

Uncommon side effects may include sudden severe headaches, tenderness, and swollen stomachs. Rare side effects may include increased blood potassium levels, hair loss, osteoporosis (weak and brittle bones), tingling, numbness, and muscular weakness (especially in the lower part of the body) if you have had a spinal puncture or a spinal anesthetic, and loss of control over the intestine or bladder.

If you experience any of the following side effects after receiving Cleven 20mg/0.2ml Injection, contact your doctor immediately: severe allergic reactions (such as skin rash, itching, swelling of the face, mouth, throat, and tongue leading to difficulty in breathing or swallowing), signs of excessive bleeding (excessive weakness, tiredness, paleness, dizziness, headache or unexplained swelling), severe skin reactions (such as skin rash, itching, skin redness with blisters or peeling of the skin, which may be associated with high fever and joint pains, dark red spots under the skin), cramping pain, redness, warmth, swelling in one of the legs, breathlessness, chest pain, coughing up blood.

✔️ Quick Suggestions:

• You have been prescribed Cleven 20mg/0.2ml Injection for the treatment and prevention of blood clots.
• Cleven 20mg/0.2ml Injection increases your risk of bleeding. Be careful while shaving, using sharp objects, or cutting fingernails or toenails.
• Inform your doctor if you are also taking other medicines that increase the bleeding risk like aspirin and NSAIDs.
• To complement the treatment with Cleven 20mg/0.2ml Injection, a low cholesterol diet and regular exercise are recommended. It is important to avoid consuming alcohol and junk food items from the outside and stick to a freshly prepared home-cooked meal. Adequate rest is also essential for a speedy recovery.
• Replacing saturated fats with unsaturated fats can help reduce total cholesterol and LDL in a short time. Foods high in heart-healthy unsaturated fats such as avocados, olive oil, fatty fish, and nuts should be consumed regularly.
• Since Cleven 20mg/0.2ml Injection may lower vitamin K levels in the body, it is advisable to include foods high in vitamin K such as liver, leafy green vegetables, or vegetable oils in your diet.
• It is important to avoid alcohol consumption as it increases the risk of gastrointestinal ulcers/bleeding. Some juices such as cranberry juice, grapefruit juice, noni juice, and pomegranate juice may interact with Cleven 20mg/0.2ml Injection and lead to unwanted side effects. It is recommended to avoid these juices while taking Cleven 20mg/0.2ml Injection.
• Inform your doctor if there is bleeding from gums, nose, or wounds that lasts more than 15 minutes or if blood appears in your urine, stool, or vomit.
• Do not stop taking the medication suddenly without talking to your doctor.

✔️ Indication of Cleven 20mg/0.2ml Injection

Enoxaparin Sodium is indicated for the treatment of deep vein thrombosis, with or without pulmonary embolism, and for the treatment of unstable angina and non-Q-wave myocardial infarction when administered concurrently with aspirin. It is also used to prevent clot formation in the extracorporeal circulation during hemodialysis, for the prophylaxis of venous thromboembolic disease (prevention of blood clot formation in the veins), especially in cases related to orthopedic or general surgery, and in medical patients who are bedridden due to severe illnesses, including cardiac failure, respiratory failure, severe infections, and rheumatic diseases.

✔️ Pharmacology

Enoxaparin Sodium is a type of low molecular weight heparin that has a high anti-Xa activity and low anti-IIa or antithrombin activity. It does not increase bleeding time at the doses required for different indications. At prophylactic doses, it does not significantly affect activated Partial Thromboplastin Time (aPTT). Enoxaparin Sodium does not affect platelet aggregation or the binding of fibrinogen to platelets. The primary site of metabolism of Enoxaparin Sodium is the liver.

✔️ Dosage & Administrations of Cleven 20mg/0.2ml Injection

• Enoxaparin is a medication used to prevent and treat blood clots in various medical conditions such as surgery, restricted mobility, unstable angina, and myocardial infarction. The dosage and duration of treatment depend on the medical condition being treated and the patient's renal function.
• For prophylaxis of blood clots in abdominal surgery, hip or knee replacement surgery, and medical patients with restricted mobility, the recommended dose is 40 mg subcutaneously once daily. For hip replacement surgery, a higher dose of 40 mg subcutaneously once daily can be considered.
• For the treatment of deep vein thrombosis (DVT), enoxaparin is administered in conjunction with warfarin, with an initial dose of 1 mg/kg subcutaneously every 12 hours or 1.5 mg/kg subcutaneously once daily. The duration of treatment is usually at least 5 days or until a therapeutic level of warfarin is achieved.
• For prophylaxis of ischemic complications in unstable angina and non-Q-wave myocardial infarction, enoxaparin is administered at a dose of 1 mg/kg subcutaneously every 12 hours in conjunction with aspirin.
• For the treatment of acute ST-segment elevation myocardial infarction (STEMI), enoxaparin is administered at a dose of 30 mg intravenously as a single bolus, followed by 1 mg/kg subcutaneously once daily in patients aged less than 75 years. In patients aged over 75 years, an initial bolus is not given, and the maintenance dose is 1 mg/kg subcutaneously once daily. Enoxaparin is given concurrently with aspirin, and the treatment duration is usually 8 days or until hospital discharge.
• In patients with severe renal impairment (creatinine clearance less than 30 mL/min), the dosage of enoxaparin needs to be reduced for all medical conditions. The recommended dose is 30 mg subcutaneously once daily for prophylaxis in abdominal surgery, hip or knee replacement surgery, and medical patients with restricted mobility. For DVT treatment, non-Q-wave myocardial infarction, and acute STEMI, the recommended dose is 1 mg/kg subcutaneously once daily.

✔️ How to administer Cleven 20mg/0.2ml Injection

• Only a doctor or nurse will administer Cleven 20mg/0.2ml Injection into a vein (intravenously) or beneath the skin (subcutaneously).
• Patients can also self-administer it if their doctor recommends it. In the case of self-administration, carefully follow the doctor's recommendations.
• Depending on your age, body weight, and medical state, your doctor will determine the appropriate dose and length of therapy for you.

✔️ Interaction

• It is important to note that Cleven 20mg/0.2ml Injection is a medication used to prevent blood clots and should only be used under the supervision of a healthcare provider. Before taking Cleven 20mg/0.2ml Injection, it is important to inform your doctor or pharmacist about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements.
• As you mentioned, Cleven 20mg/0.2ml Injection may interact with painkillers (such as aspirin and ibuprofen) and blood thinners (such as heparin, warfarin, and rivaroxaban), which can increase the risk of bleeding. Therefore, it is important to inform your healthcare provider if you are taking any of these medications.
• Cleven 20mg/0.2ml Injection may also interact with medications used to treat asthma, such as prednisolone and dexamethasone, as well as medications that increase potassium levels in your blood, such as potassium salts and water pills. Additionally, it may interact with alcoholic beverages, so it is important to avoid consuming alcohol while using this medication.
• Furthermore, it is important to inform your healthcare provider if you have any underlying medical conditions, such as liver disease, peptic ulcer disease, hypertension, kidney disease, or bleeding problems, as these conditions may increase the risk of side effects associated with Cleven 20mg/0.2ml Injection.
• In conclusion, it is important to inform your healthcare provider about all medications and medical conditions before taking Cleven 20mg/0.2ml Injection to avoid any potential interactions or complications.

✔️ Contraindications

Patients with known touchiness to Enoxaparin Sodium, heparin, or other moo atomic weight heparins. Patients with dynamic major dying and conditions with a tall chance of uncontrolled hemorrhage counting later hemorrhagic stroke.

✔️ Pregnancy & Lactation

Enoxaparin Sodium is classified as a Pregnancy Category B medication, which means that there have been no adequate and well-controlled studies in pregnant women, but animal studies have not shown any adverse effects on the fetus. It is not known whether Enoxaparin Sodium can cross the placental barrier in humans. Therefore, it should be used during pregnancy only if needed.

Pregnant women who have mechanical prosthetic heart valves may have a higher risk of thromboembolism, and Enoxaparin Sodium may be required to manage this risk. However, the decision to use Enoxaparin Sodium during pregnancy should be made after weighing the benefits against the potential risks to the fetus.

It is not known whether Enoxaparin Sodium is excreted in human milk. However, many medications are excreted in human milk and may cause serious adverse reactions in nursing infants. Therefore, a decision should be made to discontinue nursing or to discontinue Enoxaparin Sodium, taking into account the importance of Enoxaparin Sodium to the mother and the known benefits of nursing.

✔️ Precautions & Warnings

• It is important to always follow the prescribed dosage and administration of Cleven 20mg/0.2ml Injection. Do not exceed the recommended dose or use it for longer than prescribed. If you miss a dose, contact your doctor immediately to discuss the next steps.
• If you experience any side effects while using Cleven 20mg/0.2ml Injection, such as bleeding or bruising, abdominal pain, skin rash, or difficulty breathing, contact your doctor immediately. In case of an emergency, seek medical attention immediately by calling your local emergency services or going to the nearest hospital.
• It is also important to store Cleven 20mg/0.2ml Injection at room temperature, away from direct sunlight and heat sources. Keep it out of reach of children and pets. Do not use the medication after the expiration date printed on the packaging.
• Overall, Cleven 20mg/0.2ml Injection is a medication that requires careful monitoring and management by a healthcare professional. It is important to keep all appointments with your doctor and to report any changes in your health status.

✔️ Storage Conditions

Cleven 20mg/0.2ml Injection injections should be stored at a temperature of 25°C and should not be frozen. 

✔️ Disposal

Once a multiple-dose vial is opened, it should not be used for more than 28 days. If you notice any unusual color or particles in the solution, or if the syringe is damaged, you should discard the injection. It is important to read the package leaflet before using the medication and to ask the pharmacist if you have any questions or concerns.